6
Apr 2026
Researchers found that depressed inpatients with high masculine depression scores had a substantially greater acute mental health burden across multiple symptom domains, even after accounting for overall depression severity. The paper also found this pattern was not specific to men, supporting “masculine depression” as a descriptive, sex-independent behavioral profile rather than a male-only condition.
6
Apr 2026
This review argues that gut microbes and the metabolites they produce, especially SCFAs and TMAO, may shape how the heart responds to myocardial infarction through epigenetic pathways such as DNA methylation, histone modification, and non-coding RNAs. It also outlines potential intervention routes, including diet, probiotics, postbiotics, and metabolite-targeted therapies, while noting that much of the evidence remains translational and not yet clinically definitive.
6
Apr 2026
Researchers built the Extreme Environment Microbiome Catalog from 78,213 genomes across global extreme habitats, revealing major taxonomic and biosynthetic novelty, including 32,715 representative species, nearly 4 billion non-redundant genes, and 163,693 biosynthetic gene clusters. They then used protein language models to identify 3,032 candidate non-toxic antimicrobial peptides, with 84 of 100 synthesized peptides showing antibacterial activity and low cytotoxicity in the 50 tested in mammalian cells.
6
Apr 2026
In Danish adults aged 40 years or older, laboratory-confirmed influenza was linked to a sharp short-term rise in first-time heart attack and stroke risk, especially in the first 7 days after infection. Prior same-season influenza vaccination was associated with about half the excess cardiovascular risk among infected individuals, suggesting possible protection even in breakthrough cases.
6
Apr 2026
A new ACC/AHA dyslipidemia guideline and editorial argue that guideline development is rigorous but can lag behind fast-moving science, using the VESALIUS-CV trial as a clear example. The trial showed that intensive LDL cholesterol lowering with evolocumab reduced cardiovascular events in high-risk patients without prior heart attack or stroke, with implications for future guideline updates.
6
Apr 2026
Mayo Clinic researchers have developed a new method to identify which proteins are most likely to trigger an immune response - a discovery that could help improve transplant care, regenerative medicine and other areas where the immune system plays a critical role.
6
Apr 2026
Mayo Clinic researchers developed an experimental nanotherapy that delivers two cancer drugs directly to brain tumors, according to a study published in Communications Medicine.
6
Apr 2026
For decades, scientists have been carefully unraveling the role of genes in disease by examining how small variations in a person's genetic code can shape lifelong risk of developing common conditions such as cancer, diabetes, or heart disease.
6
Apr 2026
JMIR Publications today announced the release of a timely new article in its News and Perspectives section, showcasing the transformative potential of precision oncology.
6
Apr 2026
When 57-year-old Brooklyn resident Timothy Rhonda visited Park Ridge Family Health Center at NYU Langone with dangerously high blood pressure, he worried he might once again end up in the hospital.
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