12
Dec 2025
Distinct transcriptomic profiles guide early development of maxillary and mandibular teeth
The interaction between genetics and tissue environment shapes how individual teeth form in different regions of the jaw.
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12
Dec 2025
AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers
Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers.
_6e98296023b34dfabc133638c1ef5d32-620x480.jpg "Maxillary nerve block may reduce perioperative opioid consumption in pediatric primary clefts")
12
Dec 2025
Maxillary nerve block may reduce perioperative opioid consumption in pediatric primary clefts
For infants undergoing cleft palate surgery, local anesthetic injection targeting the maxillary nerve of the face may reduce or eliminate the need for opioid medications to control postoperative pain, reports a study in The Journal of Craniofacial Surgery.
12
Dec 2025
Mass General Brigham launches AI company to enhance clinical trial matching
Mass General Brigham is announcing the spinout of AIwithCare, a company founded by researchers from the health system who developed an artificial intelligence (AI) screening tool that significantly outperformed manual screening for determining a patient's eligibility and enrolling them in a clinical trial.
12
Dec 2025
Acupuncture improves breast cancer survivors' perceived cognitive impairment
Real and sham acupuncture were more effective at improving breast cancer survivors' perceived cognitive impairment compared with usual care, while real acupuncture was superior to sham acupuncture in improving objective cognitive function, according to results from the randomized ENHANCE phase II clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.
12
Dec 2025
Menopausal hormone therapy shows no added breast cancer risk for BRCA carriers
Using menopausal hormone therapy (MHT) was not associated with an increased risk of breast cancer in women with inherited mutations in the BRCA1 or BRCA2 genes, according to the results of a matched prospective analysis presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.
12
Dec 2025
Mobile health intervention improves quality of life for adolescent and young adult breast cancer survivors
A mobile health (mHealth) intervention for adolescent and young adult breast cancer survivors that offered tailored support by monitoring electronic patient-reported outcomes (ePROs) significantly improved quality of life and symptoms related to vaginal and arm problems, according to results from a randomized clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.
12
Dec 2025
Researchers identify chromatin accessibility changes driving stem cell transformation in MDS
Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation.
12
Dec 2025
Most clinical trials fail to reflect America’s racial and ethnic diversity
A new study finds just 6% of clinical trials used to approve new drugs in the U.S. reflect the country's racial and ethnic makeup, with an increasing trend of trials underrepresenting Black and Hispanic individuals.
12
Dec 2025
Plant-based diets support healthy growth when properly planned for children
Vegetarian and vegan diets can support healthy growth when carefully planned with appropriate supplementation, finds a major new meta-analysis – the most comprehensive study to-date of plant-based diets in children.
